![]() ![]() Depending on the disease condition, additional mechanisms that can contribute to an elevated physiological dead space measurement include shunt, a substantial increase in overall V'A/Q' ratio, diffusion impairment, and ventilation delivered to unperfused alveolar spaces. Effects of changes in alveolar ventilation on arterial blood PCO2 and PO2. For the range of physiological abnormalities associated with an increased physiological dead space measurement, increased alveolar ventilation/perfusion ratio (V'A/Q') heterogeneity has been the most important pathophysiological mechanism. This volume is considered to be 30 of normal tidal volume (500 mL) therefore, the value of anatomic dead space is 150 mL. Although a frequently cited explanation for an elevated dead space measurement has been the development of alveolar regions receiving no perfusion, evidence for this mechanism is lacking in both of these disease settings. Thanks for watching Share my channel as much as you can.And you can also invite your batchmates to my telegram page Connect with me on :Facebook page- ht. Anatomical (serial) dead space is the volume of air that never reaches alveoli and therefore never participates in respiration. Anatomical dead space is represented by the volume of air that fills the conducting zone of respiration made up by the nose, trachea, and bronchi. This in turn affects the acid base balance of. An elevated physiological dead space, calculated from measurements of arterial CO2 and mixed expired CO2, has proven to be a useful clinical marker of prognosis both for patients with acute respiratory distress syndrome and for patients with severe heart failure. Depending on the respiratory rate and the amount of dead space, alveolar ventilation and gas exchange will occur. ![]()
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